Mammalian-derived collagen is genetically closest to humans and therefore, least likely to cause allergy or rejection. It is necessary to draw collagen from big mammals such as sheep, pigs and cows that can be cultivated domestically
in large numbers.
A good warm-blooded source. Chicken and ducks represent the most common source, but these animals are not genetically close to mammals and have a tendency to be contaminated
by the Avian Flu.
Toxic heavy metals in the World’s oceans and seas are a growing concern. Fish are susceptible to contamination such as metals, mercury, lead and arsenic. Additionally, fish are cold-blooded and therefore, not genetically close to human.
The medical definition of collagen is “an insoluble fibrous protein of vertebrates that is the chief constituent of the fibrils of connective tissue (as in skin and tendons) and of the organic substance of bones and yields gelatin and glue on prolonged heating with water”. Despite this definition, collagen can be described as soluble in some industry sectors. Soluble collagen extracted from animals usually arises when the source is younger animals, eg lambs rather than sheep. The amount of cross linking between collagen fibers is significantly lower and it is this that gives the collagen its “solubility”. Soluble collagen is thought to penetrate skin more efficiently and has been traditionally used in cosmetics, including injectables. In medical applications, soluble collagen is often the substrate of choice to act as a delivery mechanism for pharmaceutical excipients.
Native collagen is essentially the fully formed, mature version. It’s has a very high molecular weight and it is a very large molecule. It characteristically exhibits low immunogenicity and is resistant to enzymic degradation. In medical applications this sort of collagen is suitable for soft tissue repair and is sold in sheets or sponges for wound care and treatment of burns. It is used in orthopedic applications and to generate artificial blood vessels and valves.
This type of collagen is most commonly used in cosmetics (mainly for topical application) and vitamin/nutritional supplements. Hydrolyzed collagen is formed by taking mature collagen and chemically “chopping it up into tiny bits", to create a gelatin or collagen powder.
OviGenex sources collagen from veterinary-controlled, traceable, USDA approved, disease-free sheep. Request a sample or order your CollOvine products below.